Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity (REAL-BODY)
Foundation for the National Institutes of Health
Summary
The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devices, including: bioelectrical impedance analysis (BIA) devices, 3-dimensional optical imaging (3DO), manual anthropometry measurements, dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and blood tests. The secondary study purpose is to compare body composition measurements from BIA devices, 3DO, and manual anthropometry measurements within a 1-week period for a subset of the study population. The study plans to enroll 300 healthy (having no life-threatening conditions or diseases; male and female) participants, 18 years of age or older.
Description
Obesity is a disease of excess and abnormal distribution of adipose tissue. Even though negative metabolic outcomes of obesity are driven by adipose tissue, investigators still use body weight (comprised of both fat and fat-free mass) in the calculation of body mass index (weight in kg divided by height in meters squared) to define, subclassify and monitor treatment in people with obesity. Despite this traditional focus on body weight, body composition is an important consideration in the management of people with obesity. Clinical trials and clinical research often use DXA and MRI to quantif…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * Being willing to provide written informed consent prior to participation Being willing to complete the study visits and comply with the study procedures * Being willing to travel to the various study locations for On-site, DXA, MRI, and Phlebotomy visits * Being willing to change into appropriate form-fitting clothing for 3DO assessments and/or appropriate gowns for DXA and MRI imaging * Must have a BMI within the range of 18.5 - 45 kg/m2 * Being willing to refrain from all food, drink, and substances for 8 hours prior to the On-site visit(s) and phlebotomy visit * Being…
Locations (3)
- Exponent PhoenixPhoenix, Arizona
- Exponent Menlo ParkMenlo Park, California
- Exponent BostonBoston, Massachusetts