New York State Psychiatric Institute
The purpose of this study is to learn whether a research neurofeedback training approach done during MRI scans may help reduce hallucinations such as the experience of hearing voices persistent despite treatment.
The overall objective of the current study is to assess the target engagement and efficacy of active decoded neurofeedback (DecNef) as measured by how closely a participant's brain activity aligns with the desired non-AVH-related activation pattern and improvements in AVH measured via the Auditory Hallucination Rating Scale (AHRS). Dose-response curves of target engagement over sessions will be generated.
Inclusion Criteria: * Individuals aged 18 to 55, inclusive at screen * Capable of understanding the study procedures and willing and able to provide informed consent * Diagnosed with schizophrenia or schizoaffective disorder * Taking an antipsychotic medication at a stable dose for at least 4 weeks. All oral and depot antipsychotics are allowable. * Mean Auditory Hallucination Rating Scale (AHRS) score \>2 (moderate) and AHRS Frequency ≥ 4 (hourly AVH: Frequent at least 3 to 6 per hour). * Meeting the decoder performance criterion, operationalized as ≥ 55% decoding accuracy. Baseline MRI may…
In this study participants will be randomly assigned to either active or control decoded neurofeedback.
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