University of Illinois at Urbana-Champaign
Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship remain unclear. This study will examine whether breast tissue may locally metabolize alcohol by measuring alcohol-related compounds in paired blood and breast milk samples from lactating women. The findings may help clarify alcohol-related biological pathways relevant to breast cancer risk and improve risk communication.
Alcohol consumption has been associated with an increased risk of female breast cancer, including at low levels of intake. The biological mechanisms underlying this association are not fully understood. One proposed pathway involves the metabolism of alcohol to alcohol-related compounds that may affect tissue biology. This study will examine alcohol metabolism in lactating women using paired blood and breast milk samples collected after low-level alcohol exposure. Human milk provides a non-invasive way to study biological processes occurring in the breast during lactation. By comparing alcoho…
Inclusion Criteria: All aims -Drink alcohol (at least one alcoholic drink during lactation of a lactating female) For aims 1 and 2 * Nursing a 2- to 5-month-old infant * Experienced with a breast pump Exclusion Criteria: * Pregnant * Lifetime history of alcohol dependence * Drink more than 3 standard drinks per day or more than 7 standard drinks per week in the month previous to enrollment * Current regular use of drugs with addiction potential (other than alcohol) * Use of medications known to interact with alcohol metabolism * Current smoking * Anemia * Diabetes * Liver disease
Participants will consume a protocol-specified low-level alcohol exposure under study conditions. The assigned dose and biospecimen collection procedures will vary by study group.
Breast pumping before or after drinking \~ 1 standard drink or placebo drink
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