The Effects of Exercise on Colorectal Cancer Promotion Following Pelvic Radiotherapy for Prostate Cancer

Summary

This clinical trial evaluates the effects of exercise therapy on signs of colorectal cancer in colon tissue and blood in people who completed pelvic radiation therapy for prostate cancer. People who get radiation in the pelvic area have a higher chance of developing colon cancer years later. This is because radiation can cause new mutations and inflammation. Research shows that exercise lowers colon cancer risk by about 30%. The results of this trial may help researchers better understand how exercise affects the development of colorectal cancer in patients who were treated with pelvic radiation therapy for prostate cancer.

Description

Eligibility

Age range

40–80 years

Sex

Male

Healthy volunteers

No

Interventions

• Other
  Aerobic Exercise

  Participate in individualized walking sessions

• Procedure
  Biopsy Procedure

  Undergo biopsy

• Procedure
  Biospecimen Collection

  Undergo collection of blood sample

• Procedure
  Colonoscopy

  Undergo SOC colonoscopy

• Other
  Data Collection

  Undergo collection of Apple Health data

• Other
  Physical Performance Testing

  Ancillary studies

• Other
  Questionnaire Administration

Locations (2)