Vanderbilt University Medical Center
The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pressure (SSBP). The main questions it aims to answer are: * SSBP correlates with Na+-induced changes in gut microbiome composition * Na+-induced changes in the gut microbiome and SSBP are associated with altered metabolism and with immune cell activation * Microbiota from humans with SSBP induce inflammation and hypertension in germ-free mice. Researchers will quantify SSBP from 24-hour ambulatory BP monitoring in a randomized crossover design, using standardized one week low- and high-salt diets. Participants will: * Take high- and low-salt diet each for one-week * Complete three study visits, with each visit being 1 week apart * Complete a 72-hour dietary log
Salt-sensitivity of blood pressure (SSBP), quantified as the change in 24-hour ambulatory mean arterial pressure (MAP) from one week of high-salt to one week of low-salt diet, is an independent predictor of death due to cardiovascular events. SSBP affects nearly 50% of the hypertensive and 25% of the normotensive population. Strong evidence indicates that reducing sodium (Na+) intake decreases blood pressure and cardiovascular events, however the precise mechanisms of how dietary Na+ contributes to BP elevation and cardiovascular disease remain unclear. The gut is the first and largest locatio…
Inclusion Criteria: 1. Age ≥ 50 years and ≤ 70 years. 2. Omnivore. 3. Willing to adhere to the study protocol. 4. Able to provide written consent. Exclusion Criteria: 1. Unwilling to make dietary changes or otherwise adhere to the study protocol. 2. Contraindications to high- or low-salt diet (e.g. heart, renal, or liver failure, postural orthostatic tachycardia syndrome) 3. Use of salt tabs, fludricortisone, or midodrine. 4. Contraindications to 24-hour ambulatory blood pressure monitoring, e.g. bilateral upper extremity lymphedema. 5. Medical contraindications to foods, e.g. celiac diseas…
To quantify salt sensitivity of blood pressure, each participant will consume a high-salt diet and a low-salt diet, with each diet lasting one week.
Arctuva estimate
Verify or correct the compensation shown for this listing.