Merck Sharp & Dohme LLC
Researchers are looking for new ways to treat certain types of advanced solid tumors. Solid tumors are cancers mostly in organs and tissues in the body, not in the blood or other fluids. Advanced means the cancer has spread nearby or to other parts in the body and cannot be removed with surgery. In this trial, researchers want to learn if the trial medicine called MK-2010, given alone or with other treatments, can treat advanced solid tumors. MK-2010 is designed to help the immune system fight cancer. The goals of this trial are to learn: * About the safety of MK-2010 as monotherapy and in combinations and if participants tolerate them. Tolerate means participants will receive trial treatment unless they need to stop it due to health problems. * How many participants who receive MK-2010 as monotherapy and in combination respond to treatment. Respond means the cancer gets smaller or goes away.
Inclusion Criteria: * Has radiographically measurable disease per protocol * If to receive oral study treatment, has the ability to swallow and retain oral medication and does not have gastrointestinal abnormalities that may alter absorption * Has well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART) if diagnosed with HIV * Has adequate organ function per protocol Exclusion Criteria: * Has a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease if diagnosed with HIV * Has a history of posterior reversible encephalopathy syndrome (PRES) or seizure d…
Administered as an intravenous (IV) infusion.
Administered intravenously as 400 mg every 6 weeks.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered orally as 120 mg daily.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered intravenously per approved product label.
Administered per approved product label as rescue medication.