University of North Carolina, Chapel Hill
The purpose of this randomized, double-blind, parallel-group trial is to compare the effects of two doses of creatine monohydrate (5 g/day versus 10 g/day) administered for four weeks in postpartum women. The study will evaluate exercise performance, post-exercise recovery, cognitive function, and brain creatine concentrations in a sub-sample.
Postpartum women frequently experience changes in physical performance, recovery, cognition, sleep quality, and mood. Creatine supplementation may enhance energy availability in skeletal muscle and brain tissue, potentially improving exercise performance, recovery, and cognitive function. This study will enroll 40 postpartum women and randomly assign participants in a 1:1 ratio to receive either 5 g/day or 10 g/day of creatine monohydrate for four weeks in a double-blind fashion. Assessments will be conducted before and after supplementation and will include repeated sprint ability testing, sk…
Inclusion Criteria: * 6 weeks -12 months postpartum * Body mass index of 18.5-34.9 kg/m2 * Cleared to resume physical activity Exclusion Criteria: * Experienced a musculoskeletal injury, excluding a Cesarean delivery,within the past three months that inhibits participation in the study. * Has chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer * Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids). * Has uncontrolled hypertension or diabetes, or has recently started medication, without a stabl…
Creatine monohydrate taken daily mixed with 6-8 oz of water.
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