Abramson Cancer Center at Penn Medicine
The purpose of this research study is to investigate the relationship between vascular habitats and treatment response AND to investigate the potential utility of dynamic contrast enhanced (DCE)-MRI derived parameters in predicting treatment response. This data can be used to assist in the development of a clinical decision support (CDS) tool for risk categorization and individualized decision-making. While "low-risk" patients could benefit from de-escalated radiation therapy, "high-risk" patients could receive early initiation of targeted therapies, or immunotherapies.
The current standard of care treatment for inoperable human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) patients includes concurrent cisplatin and radiation therapy with a total dose of 70Gy over a period of 7 weeks. As reported by our group and others, the full dose of CRT regimen is associated with a considerable acute and chronic toxicity profile, negatively impacting the quality of life of OPSCC patients. Moreover, treatment related morbidities result in adverse social and economic consequences. Given that HPV-positive OPSCCs are more chemo-radiosensitive in…
Inclusion Criteria: * Adult population (≥18 years) of both genders * Biopsy confirmed diagnosis of OPSCC * Known HPV status as determined by p16 immunohistochemistry (p16 positivity defined as \>70% of carcinoma cells showing nuclear reactivity) or polymerase chain reaction (PCR) sequencing * Prior to any treatment except for incisional or excisional biopsies * T0 to T4, N1 to N3, M0 (American Joint Committee on Cancer, 8th edition) * A willingness to undergo multiple phlebotomy (blood withdrawal) during standard CRT for liquid biopsy analyses. Exclusion Criteria: * HPV- negative OPSCC * Pr…
Magnetic Resonance Imaging (MRI) is a type of scan that uses radio waves to take detailed pictures of the body. You will be asked to lie on an MRI table where the technologist will place a receiver on the part of your body to be studied. You will be provided a blanket for comfort and earplugs since the MRI makes noises while it is scanning. You will still be able to hear some sound to ensure you can communicate with the technologist and can follow any direction given throughout the MRI scan. The technologist will slowly slide you into the MRI magnet where radio waves will be transmitted into you.
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