Cedars-Sinai Medical Center
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults with obesity.
During the ESG procedure, a specially trained doctor uses a flexible tube passed through the mouth to place stitches inside the stomach. This makes the stomach smaller so people feel full sooner and eat less, which can help with weight loss. The procedure uses the OverStitch Endoscopic Suturing System and is performed by trained gastroenterologists or surgeons. The study is for adults with obesity who have a BMI between 30 and 50 and have not been able to lose weight or keep it off through diet, exercise, or other non-surgical approaches. The goal of the study is to learn whether weight loss…
Inclusion Criteria: * BMI 30-50 kg/m2 * Stable weight within the 3-months prior to enrollment (\< 5 % weight loss or gain) * Documented heart failure, defined by satisfying at least one of the below criteria, with left ventricular ejection fraction ≥ 45% at time of screening * Elevated left ventricular filling pressures * Elevate natriuretic peptide levels * Echocardiographic abnormalities consistent with HFpEF * Hospitalization for heart failure in prior 12 months plus ongoing treatment with diuretics * NYHA Functional Class II-IV * KCCQ-CSS score \< 90 * 6-minute walk test \> 100 m * No hos…
The endoscopic sleeve gastroplasty (ESG) is a minimally invasive, non-surgical weight-loss procedure. During the procedure, a flexible endoscope is passed through the mouth into the stomach. Using the OverStitch Endoscopic Suturing System, the physician places a series of sutures to reduce the stomach's volume.
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