University of Colorado, Denver
This is an interventional study of a cohort of patients with PD treated with DBS, and already utilizing adaptive DBS (dual threshold mode). In Aim 1, we will obtain baseline sleep and basal ganglia physiology data to inform aDBS parameter changes. Aim 2 involves 15 nights of in-home monitoring of subjective and objective sleep quality, during which participants will use 3 different sleep-tailored aDBS settings at night only. Participant preference among these 3 settings will determined the 'optimized sleep-tailored aDBS mode'. Participants will undergo repeat polysomnography, while in the optimized sleep-tailored aDBS mode, to compare aDBS behavior and sleep architecture to the baseline (Aim 1) sleep study.
Parkinson disease (PD) is the second most common age-related neurodegenerative disease worldwide, and is the fastest growing neurologic disorder in prevalence, disability, and deaths. Sleep disturbances have a significant negative impact on quality of life for patients with PD and their caregivers, and may be correlated with faster disease progression. Poor sleep is a known risk factor for cognitive impairment in PD. PD patients spend less time in non-rapid eye movement (NREM) stage 3 (N3) and REM sleep, both of which are critical for memory consolidation and integration with existing knowledg…
Inclusion Criteria: * Adult patients, in the age range of 45 to 75 years (inclusive) * Have a smart phone and be willing and able to download the app required for the Waveband and SEMA3 * Are able to use the Waveband app * Diagnosis of idiopathic PD and treatment with STN or GPi DBS using the Medtronic system, including SenSight (model B33005 or B33015) leads and Percept RC (model B35300) implanted pulse generator * Hoehn and Yahr stage 2-3 (on medication, on DBS) at the time of enrollment * Taking unchanged doses of antiparkinsonian medications for at least 4 weeks prior to study enrollment.…
Participants will use 3 different sleep-tailored aDBS settings at night only. Participant preference among these 3 settings will determined the 'optimized sleep-tailored aDBS mode'.
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