Yale University
The primary objective of this study is to evaluate the 5-year (60-month) allograft survival rate of upper extremity vascularized composite allotransplantation performed under the standardized CONSORT clinical protocol.
The study population includes adults with severe upper extremity disfigurement meeting the following criteria: * Anatomic Severity: Loss of upper extremity proximal to the wrist (including transhumeral and shoulder-level levels when clinically appropriate) * Refractory Status: prosthesis delivered unsatisfactory results
Inclusion Criteria: Participants: * Competent to provide informed consent, as determined through structured clinical assessment by qualified study personnel, and able to demonstrate adequate psychosocial support, including caregiver or other support-person assistance as needed, to facilitate postoperative recovery, adherence to immunosuppressive therapy, and long-term study follow-up. where feasible, to support psychosocial and aesthetic integration. * Willingness to undergo comprehensive psychosocial evaluation and ongoing monitoring by the multidisciplinary team. * Demonstrated motivatio…
Upper Extremity VCA, performed to treat severe facial defects. This procedure will be performed by qualified surgeons in accordance with standard institutional surgical practices.