Phage-CLEAR: Phage-based Control and Limitation of Pathobionts for Microbiome Equilibrium and Resilience
Colorado State University
Summary
Bacteriophages are viruses that can selectively infect specific species and strains of bacteria. Some bacterial species in the human gut have been negatively associated with gut health and skin health. This study is designed to measure the efficacy of two different bacteriophage-based treatments for 4 weeks to improve gut and skin health. These treatments are bacteriophage that target specific strains of Escherichia coli and Staphylococcus Aureus.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Between 18-75 years old * BMI \<30 * Experiencing mild-moderate gastrointestinal distress/ abdominal pain, bloating, constipation, and/or diarrhea Exclusion Criteria: * Younger than 18 years old or greater than 75 years old * BMI \>29.9 * Antibiotic use in the past 2 months * Use of statins, metformin, prescription NSAIDs, and MAO inhibitors, or other medications that could interfere with study outcomes, as determined by the study PI * Current diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, or cardiometabolic disease (diabetes, cardiovascular d…
Interventions
- Dietary SupplementBacteriophages - MuniPhage
1 x 106 Plaque Forming Units (PFU) of bacteriophage strains PBH34, CAH57, BFX121, and DNK95
- Dietary SupplementBacteriophages - RenuPhage
1 x 106 PFU of phage strains LG91, BD117, CD007, and PD23
- OtherPlacebo
Rice maltodextrin
Location
- Colorado State UniversityFort Collins, Colorado