Emory University
This study will evaluate whether a fully provided, unrefined, polyphenol-rich plant-based diet can improve blood vessel function in adults with coronary microvascular dysfunction (CMD), a condition that causes reduced blood flow in the small vessels of the heart despite the absence of major coronary artery blockages. Participants will follow the diet for 12 weeks while continuing their usual medical care. Researchers will assess changes in vascular function, symptoms, blood pressure, blood lipids, and other health measures throughout the study. Participants have up to 60 days after consent to complete screening and pre-intervention baseline assessments, potentially over two visits. Day 0 is counseling/education, and diet initiation. Weeks 4, 8, and 12 are measured from Day 0.
Coronary microvascular dysfunction (CMD) is characterized by impaired coronary microvascular vasodilation and reduced coronary flow reserve in the absence of obstructive epicardial coronary artery disease. CMD is a common cause of ischemic symptoms and is associated with persistent angina, reduced quality of life, and increased cardiovascular risk. Existing therapies are largely directed toward symptom management, and additional strategies that address underlying disease mechanisms are needed. Oxidative stress, impaired nitric oxide bioavailability, and abnormalities in vascular function are…
Inclusion Criteria: * Women must be postmenopausal. * History of angina, ischemic symptoms, or symptoms consistent with ischemia in the absence of obstructive coronary artery disease. * No obstructive coronary artery disease (\<50% stenosis in any epicardial coronary artery or fractional flow reserve \>0.80). * Clinically documented coronary microvascular dysfunction (CMD), including coronary flow reserve \<2.5 and/or index of microcirculatory resistance ≥25, or equivalent documentation in the medical record. * Stable cardiometabolic medication regimen for at least 2 months before enrollment.…
A fully provided, weight-maintaining, unrefined, polyphenol-rich plant-based dietary intervention administered for 12 weeks. The diet is designed around whole plant foods, including fruits, vegetables, legumes, whole grains, nuts, and seeds, and excludes animal products, refined grains, added sugars, sugar-sweetened beverages, and commercially processed plant-based meat or cheese substitutes. Participants receive nutrition education, ongoing dietary counseling, meal provision, and vitamin B12 supplementation throughout the intervention period
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