Cedars-Sinai Medical Center
The purpose of this study is to examine how the brain processes faces, which are some of the most important stimuli that we view, process, and make decisions about as we go through daily life. This project examines the dynamics of where and when in the brain information conveyed by faces is represented, how such information is modulated by context and goals, and how such information is used to make decisions about faces.
Despite the importance of faces for decision making, little is known about the neural mechanisms of how information conveyed by faces is extracted and used to inform decisions we make. The goal of this research is to develop a circuit-level understanding of face processing. As part of this study, investigators will conduct experiments that utilize the rare opportunity to record in-vivo from human single neurons simultaneously in multiple brain areas in patients undergoing treatment for drug resistant epilepsy. Researchers will investigate three overarching hypotheses on the neural substrate o…
Inclusion Criteria: * Intractable epilepsy, undergoing invasive monitoring * Age ≥18 * Full Scale Intelligence Quotient \> 70 * Ability to comprehend and perform simple behavioral tasks by pressing buttons on laptop computer in response to questions. Exclusion Criteria: * Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain.
Devices listed are components of a single intervention that includes: Record patient responses (Cedrus RB-844), record neuronal activity (Neurolynx) from electrodes (Adtech Behnke-Fried), apply intermittent electrical stimulation (Blackrock Cerestim)
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