University of Miami
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.
Inclusion Criteria: * Established HIV infection * Glove/stocking dysesthesias lasting for ≥3 months * HIV-associated peripheral neuropathy (HIV-PN) related symptoms ≥4 (on a scale of 0-10) within the last week * Stable medical care (i.e., no changes in Antiretroviral Therapy or pain medication within 2 months of enrollment) * Able to read the consent form, demonstrate understanding of study procedures and requirements, and independently provide written informed consent Exclusion Criteria: * Unstable cardiac disease * Implanted electronic or magnetic devices (e.g., pacemaker, cochlear implan…
Transcutaneous auricular vagus nerve stimulation (taVNS) will be administered at the cymba concha using hydrogel electrodes and a Digitimer DS8R biphasic constant-current stimulator. Participants will receive 90-minute stimulation sessions consisting of monophasic pulses (pulse width: 500 microseconds; frequency: 25 Hz; duty cycle: 50%). Stimulation intensity will be set at 200% of the participant's sensory perception threshold and may be adjusted up to 5 milliamperes (mA) while remaining below the pain threshold.
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