University of California, San Francisco
The TRIUMPH study is a randomized, double-blinded, 3-arm, parallel-group trial designed tocompare the effects of anticholinergic bladder therapy versus a) beta-3-adrenergic agonistbladder therapy and b) no bladder pharmacotherapy on cognitive, urinary, and other aging-related functional outcomes in ambulatory older women with urgency-predominant urinaryincontinence and either normal or mildly impaired cognitive function at baseline.
Inclusion Criteria: * Aged 60 years or older at the time of enrollment * Female sex at birth, without surgical or hormonal gender re-assignment therapy * Able to walk to the bathroom and use the toilet without assistance * Report urinary incontinence starting at least 3 months prior to screening * Report that at least half of incontinence episodes occur with a sudden or strong sensation of urgency * Report 2 or more urgency incontinence episodes over a 7-day period * Willing to provide informed consent and adhere to study procedures throughout the length of the study Exclusion Criteria: * P…
Anticholinergic
Beta-3-adrenergic agonist
matching placebo pill
Arctuva estimate
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