Brigham and Women's Hospital
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype. Taking too much salt in your food or drink also can increase your blood pressure. In this research study we want to determine if different forms of the B2AR gene and the level of salt intake act together to cause high blood pressure.
1\. Background and Significance 1. Importance of the Problem. Over 1/3 of adults in the USA have hypertension (HTN), of which 51.3% (over 34 million Americans) have uncontrolled blood pressure (BP)1, leading to a high prevalence of cardiovascular (CV) complications mediated by elevated BP1. Among the major hurdles to be addressed in HTN are: 1) the lack of specificity in treatment programs, and 2) the unclear mechanisms by which genetic and environmental factors (e.g. dietary Na+ intake) affect BP and CV function. Clearly, the first hurdle is - for the most part - a consequence of the second.…
Inclusion Criteria: * Ages 18-50 years; HTN as defined by the primary physician; on ≤ two anti-hypertensives; normal renal, liver, metabolic, electrolyte, CBC, and thyroid tests. Exclusion Criteria: * Pregnancy; renal, neurologic, and cardiac diseases other than HTN; diabetes; secondary HTN as assessed by history, physical examination, screening blood and urine tests; any drug therapy, except for anti-hypertensives and replacement thyroid medication; and no oral contraceptives/implants/ERT within 2 years of study.
Low Sodium Diet
High Sodium Diet
renal blood flow response to diet and angiotensin II by diplotype
Vasoreactivity response by diplotype
Arctuva estimate
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