University of Oklahoma
The purpose of this study is to explore pro-metastatic changes in breast cancer (BC) associated with the stiffness of biopsy site markers. This study aims to determine whether the stiffness of a biopsy site marker promotes inflammatory changes in breast cancer and to evaluate whether there is a relationship between biopsy site marker stiffness and inflammation.
This prospective study aims to evaluate whether anti-inflammatory and pro-metastatic changes at the post-biopsy site are associated with the type of biopsy-site marker used, with particular focus on marker stiffness. Tissue samples will be collected from breast cancer patients who received a biopsy-site marker at the time of diagnosis.
Inclusion Criteria: * Written informed consent (ICF) signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses. * Female patients at \> 18 years of age at the time of signature of the ICF. * Pathologically verified invasive breast cancer cases referred to OU for surgery. Exclusion Criteria: * Patients who had a biopsy at OUBI OKC. * Patient who will undergo neoadjuvant therapy * Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension, uncontrolled diabetes mellitus, active bleeding diatheses, or act…
Tissue samples will be collected from Breast Cancer patients, stages I-III, who underwent lumpectomy (mastectomy) after biopsy site marker placement during image-guided biopsy.
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