AdventHealth
The goal of this observational study is to evaluate whether hepatic artery infusion pump (HAIP) chemotherapy can improve outcomes in patients with pancreatic or duodenal adenocarcinoma who have isolated or liver-dominant metastases after surgery and systemic chemotherapy. The main questions it aims to answer are: Does HAIP chemotherapy improve liver tumor response based on imaging criteria (RECIST)? What are the progression-free survival and overall survival outcomes in this patient population? Participants will: Undergo placement of a hepatic artery infusion pump as part of standard clinical care Receive floxuridine (FUDR)-based chemotherapy through the pump Have clinical data, imaging results, and laboratory markers (e.g., ctDNA, CEA, CA 19-9) collected from their medical records over time
Detailed Study Description This study is a single-center, prospective observational feasibility study designed to evaluate the clinical outcomes of hepatic artery infusion pump (HAIP) chemotherapy in patients with pancreatic or duodenal adenocarcinoma who develop isolated or liver-dominant metastases following primary tumor resection and systemic chemotherapy. The study is conducted at AdventHealth Orlando and will enroll approximately 10 adult patients who meet predefined clinical eligibility criteria. Study Rationale Pancreatic and duodenal adenocarcinomas have a poor prognosis when metasta…
Inclusion Criteria: * Age 18-80 years * Histologically confirmed pancreatic or duodenal adenocarcinoma * Completed or currently receiving curative-intent treatment * Evidence of isolated or liver-dominant metastases (radiographic or clinical) * Deemed clinically eligible for hepatic artery infusion pump (HAIP) placement and floxuridine (FUDR)-based chemotherapy by a multidisciplinary oncology team * Scheduled for HAIP placement at AdventHealth Orlando Exclusion Criteria: \- Patients who are clinically ineligible for HAIP placement or FUDR therapy are excluded
HAIP placement for metastatic disease to the liver
FUDR-based chemotherapy
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