Amgen
The primary objective of this study to evaluate the efficacy of inebilizumab on primary membranous nephropathy (PMN) disease activity as measured by complete remission in participants with PMN.
Inclusion Criteria: * Adults aged ≥18 years and \<80 years. * Able and willing to provide written informed consent. * Primary membranous nephropathy (PMN) confirmed by renal biopsy (performed during screening or within 5 years before screening), or biopsy exemption for participants with anti-PLA2R antibody ≥20 RU/mL at screening. * Participants with diabetes Hemoglobin A1c (HbA1c) \<7.5% require a renal biopsy report within 2 years before screening (or biopsy during screening) demonstrating PMN without diabetic nephropathy. * Urine protein-to-creatinine ratio (UPCR) ≥3.5 from a 24-hour urine…
Inebilizumab will be administered via IV infusion.
Tacrolimus will be administered orally
Arctuva estimate
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