A Prospective, Randomized Study on the Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
Wills Eye
Summary
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD). While current surgical therapies successfully reattach the retina, visual recovery can vary. This study will investigate if injecting a small amount of gas (0.3 cc of 100% C3F8) into the eye prior to standard surgery can decrease the duration of macular detachment, reduce retinal displacement, and ultimately result in better final visual acuity compared to the standard of care alone.
Description
Macula-off rhegmatogenous retinal detachment (RRD) is associated with compromised visual outcomes. While current standard-of-care therapies (pars plana vitrectomy and scleral buckle) are highly effective at correcting the anatomy, functional visual recovery remains variable. Time to macular reattachment and the extent of retinal reapposition are critical factors influencing ultimate visual acuity. Small preliminary studies suggest that an intraocular gas injection performed prior to definitive surgical treatment may decrease the duration of macular detachment and minimize retinal displacement…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * A patient must meet the following criteria to be eligible for inclusion in the study: 1. Diagnosed with macula-involving primary rhegmatogenous retinal detachment 2. Consents to surgical repair with pars plana vitrectomy with or without scleral buckling 3. Willing and able to comply with clinic visits and study-related procedures Exclusion Criteria: * A patient who meets any of the following criteria will be excluded from the study: 1. Age \< 18 years old 2. Presence of PVR grade C or worse (as defined by the revised Retina Society PVR classification) at time of surgic…
Interventions
- ProcedureIntravitreal 100% C3F8 Injection
Patients with Macula off Rhegmatogenous Retinal Detachment will receive an intravitreal injection of 100% C3F8 prior to undergoing surgical repair for their condition
- ProcedurePars plana vitrectomy or pars plana vitrectomy with scleral buckle
Patients with RRD will undergo standard of care treatment of RRD with pars plana vitrectomy or pars plana vitrectomy with scleral buckle
Locations (2)
- Wilmer Eye Institute, Johns Hopkins HospitalBaltimore, Maryland
- Wills Eye HospitalPhiladelphia, Pennsylvania