Treatment of Fungal Blepharitis With Natacyn: A Prospective Interventional Study

Brent Kramer

Summary

The goal of this clinical trial is to learn if Natacyn works to reduce or eliminate laboratory-confirmed fungal organisms in subjects with fungal-positive blepharitis identified in a previous study. asthma in adults. It will also learn more about the safety of Natacyn. The main questions it aims to answer are: Does Natacyn reduce or eliminate fungal presence? Does Natacyn cause a reduction in eye irritation and itchiness? What medical problems do participants have when using Natacyn? Participants will: Apply Natacyn 4 times a day for 21 days Visit the clinic once every week for checkups and tests Keep a diary of the number of times they apply Natacyn over the 21-day period

Eligibility

Age range: 18+ years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * Age 18 years or more * Clinical diagnosis of blepharitis * Laboratory-confirmed fungal organisms from Part 1 * Willingness to comply with QID (4 times a day) dosing for 21 days * For women of childbearing potential (WOCBP): willingness to use a highly effective method of contraception (combined hormonal contraception, progestogen-only hormonal contraception with ovulation inhibition, intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomized partner, or sexual abstinence) from at least 14 days prior to first dose of Natacyn throug…

Interventions

Drug
NATACYN®
Natamycin 5% ophthalmic suspension (Natacyn®) is FDA-approved for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms (NATACYN US Prescribing Information). The route of administration in this study - application to the eye at a frequency of QID for 21 days - is consistent with the labeled dosing range for fungal blepharitis (one drop, 4 to 6 times daily).

Locations (5)

The Eye Associates
Jacksonville, Florida
jrobben@bowdeneye.com 904-296-0098
Kannarr Eye Care
Pittsburg, Kansas
skannarr@kannarreyecare.com 620-687-2845
Pure Ophthalmic Research
Mint Hill, North Carolina
doctorag@minthilleye.com 980-209-9437
CORE Inc.
Shelby, North Carolina
vollmer@researchwithcore.com 828-406-3878
Vance Thompson Vision
Sioux Falls, South Dakota
brent.kramer@vancethompsonvision.com 605-361-3937

Summary

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

Detailed criteria

Interventions

Drug

NATACYN®

Natamycin 5% ophthalmic suspension (Natacyn®) is FDA-approved for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms (NATACYN US Prescribing Information). The route of administration in this study - application to the eye at a frequency of QID for 21 days - is consistent with the labeled dosing range for fungal blepharitis (one drop, 4 to 6 times daily).