Amgen
The main objective of this trial is to evaluate whether maridebart cafraglutide is non-inferior to semaglutide in improving glycemic control in participants with type 2 diabetes (T2D) who are receiving metformin treatment, with or without a sodium-glucose cotransporter-2 (SGLT-2) inhibitor.
Inclusion Criteria: * HbA1c of ≥ 7.5% (58.0 millimoles per mole (mmol/mol)) and ≤ 10.5% (91.0 mmol/mol) at screening. * Treatment of Type 2 diabetes (T2D) with metformin (≥ 1500 milligrams per day (mg/day), or maximum tolerated dose as per investigator judgment) with or without an sodium-glucose cotransporter-2 (SGLT-2) inhibitor on a stable total daily dose for at least 90 days prior to randomization. * Body mass index (BMI) ≥ 25 kilograms per meter squared (kg/m\^2) at screening. Exclusion Criteria: * Type 1 diabetes mellitus (T1DM), history of ketoacidosis or hyperosmolar state/coma, or…
Administered subcutaneously.
Administered subcutaneously.