University of Nebraska
The primary goal of this clinical trial is to is to compare the rate of positive peripheral margins in wide local excision (WLE) performed to allow for comprehensive peripheral and deep margin assessment (CPDMA) assessment versus WLE performed with the intent of standard breadloafing of stage I-II cutaneous melanoma specimens. Secondary aims are to compare local recurrence at 1 and 2 years, the rate of re-excision due to positive margins, pathology turnaround time, pathology resource utilization, and cost per case between the two assessment methods. The main questions it aims to answer are: * Does WLE performed to allow for CPDMA have a higher rate of positive peripheral margins than wide local excision performed with the intent of standard breadloafing? * Will more complete positive margin detection support more appropriate re-excision and lower local recurrence over two years? * Does CPDMA require greater pathology resource utilization and longer turnaround time than breadloafing? Researchers will compare standard breadloafing (control) arm to CPDMA (experimental) arm. Participants will: * Undergo WLE. * Attend a follow-up visit at 4 months.
Inclusion Criteria: * Age ≥19 years * Histologically confirmed clinical Stage I or II cutaneous melanoma, inclusive of acral melanoma * Candidate for guideline (NCCN) concordant wide local excision * Able to provide informed consent Exclusion Criteria: * Prior wide local excision of the lesion * History of melanoma * Melanoma lesions at more than one site * Prior radiation therapy to the site * Pregnancy or lactation
Wide Local Excision