Johns Hopkins University
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
This clinical laboratory study will be double-blind, placebo-controlled and will utilize a within-subjects experimental design. Participants will complete 7 outpatient drug administration sessions that will consist of self-administration of oral cannabis (0, or 10mg THC; 0, 10, 50, 100, 300mg CBD). Primary outcomes include performance on cognitive and psychomotor assessments, subjective drug effects, simulated driving performance, and impact on blood pharmacokinetics.
Inclusion Criteria: * at least 21 years old; * be in good general health based on screening procedures (e.g., physical exam, EKG, blood testing, psychiatric evaluation); * have vital signs in normal range; * have not donated blood in past 30 days; * not be pregnant (assessed via blood serum at screening and urinalysis before each study session) or breast feeding (women only); * have a body mass index (BMI) in the range of 18 to 36 kg/m\^2; * report using cannabis in the last 3 years, but not in the past month; * negative urine test for illicit drug use (including THC) and negative breath alco…
Brownie containing no THC and CBD will be self administered through oral ingestion.
Brownie containing 10mg THC and no CBD will be self administered through oral ingestion.
Brownie containing 10mg THC and 10mg CBD will be self administered through oral ingestion.
Brownie containing 10mg THC and 50mg CBD will be self administered through oral ingestion.
Brownie containing 10mg THC and 100mg CBD will be self administered through oral ingestion.
Brownie containing 10mg THC and 300mg CBD will be self administered through oral ingestion.
Brownie containing no THC and 300mg CBD will be self administered through oral ingestion.
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