Targeting Cellular Senescence With Fisetin for Improving Vascular Endothelial Function in Older Adults
University of Colorado, Boulder
Summary
Aging is associated with the development of vascular dysfunction, which increases the risk for cardiovascular disease. This clinical trial will assess if supplementation with the natural compound fisetin can improve vascular endothelial function in older adults. The clinical trial will also assess if any effects of fisetin on endothelial function are associated with reduced cellular senescence. The study will also evaluate safety, tolerability and adherence with fisetin treatment.
Eligibility
- Age range
- 65+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 65 years or older * Women must be postmenopausal * Body mass index (BMI) \<40 kg/m2 * Willing to accept random assignment * Weight stable in the prior 2 months (\<2 kg weight change) and willing to remain weight stable throughout the study * Ability to understand study procedures and to comply with them for the entire length of the study * Absence of established, serious, unstable, chronic clinical disease (e.g., unstable CVD) that would make it unsafe for the individual to participate in the trial as determined by trial physician of record. Exclusion Criteria: * I…
Interventions
- Dietary SupplementFisetin
Fisetin will be administered in an intermittent manner with six three-day dosing periods at a dose of 2 mg/kg/day separated by two weeks.
- OtherPlacebo
Placebo capsules identical in appearance to fistin capsules will be administered in an intermittent manner with six three-day dosing periods separated by two weeks.
Location
- University of Colorado BoulderBoulder, Colorado