ROSETTA Lung-220: A Phase 2, Open-Label, Multicenter, Multi-Arm Platform Study Evaluating Pumitamig and Other Novel Neoadjuvant Regimens in Participants With Resectable, Early-Stage (IIA to IIIB) Non-Small Cell Lung Cancer
Bristol-Myers Squibb
Summary
The purpose of this study is to assess the safety, tolerability, and surgical feasibility of preoperative Pumitamig-based therapy and other molecules in resectable, Early-Stage Non-Small Cell Lung Cancer
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Participants must have newly diagnosed, previously untreated participants with histologically confirmed non-small cell lung cancer (NSCLC) (squamous or non-squamous histology); resectable Stage IIA to IIIB (N2) disease (American Joint Committee on Cancer (AJCC) 9th edition). * Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1. * Participants must have an evaluable programmed death-ligand 1 (PD-L1) expression. Exclusion Criteria * Participants must not have unresectable disease, N3 nodal involvement, or any evidence of…
Interventions
- DrugPumitamig
Specified dose on specified days
- DrugCarboplatin
Specified dose on specified days
- DrugCisplatin
Specified dose on specified days
- DrugPaclitaxel
Specified dose on specified days
- DrugPemetrexed
Specified dose on specified days
Locations (50)
- Local Institution - 0069Long Beach, California
- Local Institution - 0127Los Angeles, California
- Local Institution - 0136Tampa, Florida
- Local Institution - 0155Chicago, Illinois
- Local Institution - 0080Chestnut Hill, Massachusetts
- Local Institution - 0163Portland, Oregon