University of North Carolina, Chapel Hill
A Randomized, Dosing vs Standard of Care, Single-Center, Multiple Dose Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion
The objective is to confirm GGE's impact on transforming mucus to optimal form that facilitates its loosening from airway walls and improves mucociliary clearance. The investigators propose a standard of care (SOC defined as all current medications prescription and non-prescription drugs and supplements) controlled clinical trial involving 40 participants (20 GGE / 20 SOC) with stable chronic bronchitis ((defined as subjects with chronic productive cough that occurs daily for at least 3 months in 2 consecutive years, in a patient who has not had an acute exacerbation within the previous 4 week…
Inclusion Criteria: * • Confirmed diagnosis of stable chronic bronchitis (defined as subjects with chronic productive cough that occurs daily for at least 3 months in 2 consecutive years, in a patient who has not had an acute exacerbation within the previous 4 weeks; where an acute exacerbation of chronic bronchitis is defined as an acute worsening of a patient's symptoms, beyond normal day-to-day variations, necessitating a change in treatment with antibiotics and/or corticosteroids). * Ability to produce spontaneous sputum and non-reactive to hypertonic saline for induced sputum collecti…
Participants will receive 28 days (+3 days for flexible scheduling) dosing of Glycerol Guiacolate (GGE) (2 x 600 mg for a total of 1200mg) taken twice daily (total of 2400 mg) in addition to current medications.
Current medication excluding mucolytics or steroids
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