Feasibility and Effectiveness of Sentinel Lymph Node Biopsy in Inflammatory Breast Cancer
Case Comprehensive Cancer Center
Summary
This study is for participants with inflammatory breast cancer (IBC). The purpose of this study is to find out whether it is possible to take a sample of underarm lymph nodes for participants with IBC. The participants will undergo sentinel lymph node biopsy (SLNB) in addition to full axillary lymph node dissection (ALND) during the planned breast cancer surgery. Participants enrolled in the study will first be injected with tracer, then undergo SLNB, and then undergo full ALND.
Description
Inflammatory breast cancer is a rare and aggressive type of cancer where the tumor cells invade the lymphatic vessels in the skin. This causes the appearance of red and swollen breasts. Most participants are diagnosed with locally advanced disease, and the standard treatment is chemotherapy, followed by mastectomy and axillary lymph node dissection, radiation treatment, and then adjuvant therapy. But advances in therapy have called into question if mastectomy with ALND is still necessary in participants with IBC, with some physicians advocating for the option of sentinel lymph node biopsy. How…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Adult participants greater than 18 years old * Diagnosed with inflammatory breast cancer * Completion of course of Neoadjuvant Chemotherapy * Surgery completed at Cleveland Clinic Exclusion Criteria: * Participant is pregnant at the time of surgery * Pregnant participants will be excluded from participation in the study as injection of blue dye to aid in identification of sentinel lymph nodes is contraindicated in pregnancy due to the risk of fetal harm. * Metastatic disease at the time of diagnosis or diagnosed prior to surgical treatment
Interventions
- Diagnostic TestSentinel node biopsy with blue dye and radioisotope
Participants will be injected with blue dye and radioisotope tracer into the breast of tumor that drains into the first axillary lymph nodes during their planned surgical procedure so that the sentinel lymph nodes can be sampled.
Location
- Cleveland Clinic FoundationCleveland, Ohio