Johns Hopkins University
This study will evaluate the subjective and behavioral effects of psilocybin relative to placebo and alcohol.
This clinical laboratory study will be double-blind, double-dummy, placebo-controlled and will utilize a within-subjects experimental design. Participants will complete 6 outpatient drug administration sessions that will consist of self-administration of oral capsule containing placebo or psilocybin (0, 1, 5, 15, 25mg) and an alcoholic drink containing alcohol to achieve a 0.00% or 0.08% blood alcohol concentration. No drug combinations will be administered during this study. Primary outcomes include performance on cognitive and psychomotor assessments, subjective drug effects, simulated drivi…
Inclusion Criteria: * Be at least 21 years old, * Be in good general health based on screening procedures (e.g., physical exam, blood testing, psychiatric evaluation), * Have vital signs in normal range, * Have not donated blood in past 30 days, * Not be pregnant (assessed via blood serum at screening and urinalysis before each study session) or breast feeding (women only), * Have a body mass index (BMI) in the range of 18 to 36 kg/m2, * Report using psilocybin at least once in the participant's lifetime, but not in the past month, * Negative urine test for illicit drug use (not including can…
Participants will self-administer a capsule containing 0mg psilocybin and a drink that contains alcohol dosed to 0.00% BAC.
Participants will self-administer a capsule containing 1mg psilocybin and a drink that contains alcohol dosed to 0.00% BAC.
Participants will self-administer a capsule containing 5mg psilocybin and a drink that contains alcohol dosed to 0.00% BAC.
Participants will self-administer a capsule containing 15mg psilocybin and a drink that contains alcohol dosed to 0.00% BAC.
Participants will self-administer a capsule containing 25mg psilocybin and a drink that contains alcohol dosed to 0.00% BAC.
Participants will self-administer a capsule containing 0mg psilocybin and a drink that contains alcohol dosed to 0.08% BAC.
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