MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)

Summary

This is a single-center, open-label clinical study designed to evaluate alpha-synuclein (ASYN) deposition in the brain of participants with Parkinson's disease (PD), as compared with healthy elderly (HE) participants. Up to 18 participants (12 PD, 6 HE) are planned to be enrolled. Each participant will receive a single IV injection of \[¹⁸F\]MK-0947 as part of Part 1A followed by PET imaging using the Investigational United Imaging NeuroEXPLORER(NX) camera or the Siemens Biograph mCT camera. If enrolled in Part 1B a second injections and PET scan may be conducted in participants with PD and HE from Part 1A.

Description

Eligibility

Age range

40–80 years

Sex

All

Healthy volunteers

Yes

Interventions

• Drug
  [¹⁸F]MK-0947

  Participants enrolled in the study will receive up to two single IV injections of \[¹⁸F\]MK-0947 followed by dynamic PET imaging using the United Imaging NeuroEXPLORER (NX) brain PET scanner, the Siemens Biograph mCT brain PET scanner, or both.

Location