Los Angeles Brain Science Project
The goal of this clinical trial is to determine if taking four weeks of a daily low dose of tadalafil is possible and safe in elderly males and females with mild cognitive impairment. Additionally, we aim to determine if this drug that improves blood flow can improve cognition and functionality of the blood vessels in the brain. The main questions the trial aims to answer are: 1. Will elderly patients with mild cognitive impairment be able to tolerate taking a daily, low dose (5 mg) of tadalafil? 2. Does 5 mg of daily tadalafil improve cerebral vasomotor reactivity (i.e. vascular function) and cognition? Participants will to: 1. Answer questions about your health 2. Take three short thinking and memory tests 3. Have your blood pressure and heart rate checked 4. Have an electrocardiogram 5. Fill out a thinking questionnaire 6. Fill out a suicidality questionnaire 7. Have a brain blood flow test 8. Get three blood tests throughout the study 9. Take tadalafil once daily 10. Monitor your blood pressure twice daily 11. Record any side effects 12. Return after 4 weeks and repeat testing
Inclusion Criteria: * The participant is between the ages of 60-90 years old. * The participant must demonstrate a MoCA score ≥ 18 and ≤ 25. * The participant has consented for his/herself. * The participant has a caregiver, family member, or qualified individual to help with study tasks * The participant is fluent in the English language. * The participant is proficient in comprehending verbal and written English. Exclusion Criteria: 1. Any of the aforementioned CMP values meet the exclusion threshold. 2. Absence of a caregiver, family member, or other appropriately qualified individual th…
Participants will take a daily dose of 5 mg of tadalafil over a 4 week period