St. Jude Children's Research Hospital
The purpose of this study is to evaluate the practicality and acceptability of collecting biological samples and health information from childhood survivors of acute lymphoblastic leukemia (ALL) and their siblings. Participants will provide saliva, blood, hair, and fingernail samples, complete questionnaires, and participate in sleep monitoring. The information collected will help researchers understand how cancer treatment and neighborhood conditions may affect stress hormones, inflammation, and long-term health. Primary Objective \- To evaluate the feasibility of collecting multiple biological specimens, surveys, and sleep assessment among child and adolescent survivors of ALL and their siblings.
Childhood survivors of acute lymphoblastic leukemia (ALL) can experience long-term health problems after cancer treatment. Researchers believe that stress-related biological processes and social factors, such as neighborhood socioeconomic conditions, may influence long-term health outcomes. However, it is not known whether collecting multiple biological samples over several days is practical for survivors and their families. This feasibility and acceptability study will enroll survivors of childhood ALL, their siblings, and caregivers. Participants may complete study activities through a comb…
Inclusion Criteria: SURVIVORS * The survivor is a childhood survivor of Acute Lymphocytic Leukemia (ALL). * The survivor was treated on one of the following St. Jude Total Therapy Studies: 1. TOTAL Therapy study XVI for Newly Diagnosed Patients with ALL (TOTXVI) OR 2. Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma (TOT17) * The survivor is cancer-free. * The survivor is at least 5 years out from the ALL diagnosis. * The survivor is at least 2 years out from completion of treatment. * The survivor did not receive cranial therapy as part of ALL therapy. * The su…
Participants collect five saliva samples per day on three days within a 14-day period (wake, +30 min, +45 min, +60 min, bedtime) to assess diurnal cortisol rhythm and cortisol awakening response.
Collection of blood samples to measure high-sensitivity C-reactive protein, pro-inflammatory cytokines, dehydroepiandrosterone, and luteinizing hormone. Hybrid participants undergo venipuncture (\~3 mL blood). Remote participants use the FDA-approved RedDrop One capillary blood collection device.
Collection of a small hair sample from the posterior vertex of the scalp to measure long-term cortisol exposure. Hair is cut close to the scalp and stored for laboratory analysis.
Fingernail clippings from all ten fingernails are collected to measure nail cortisol levels.
FDA-approved wearable sleep assessment device used to measure sleep/wake times and sleep quality during the saliva collection period.
Participants complete brief morning and evening diaries to record sleep, caffeine intake, medication use, symptoms, stress, affect, daily events, and other factors that may influence cortisol measurements.
Electronic caps used with saliva collection tubes to record date and time of each bottle opening, providing objective assessment of saliva collection adherence.
Mobile/web-based application that provides saliva collection reminders and records sample collection timing and participant-reported wake times.
Collection of demographic, psychosocial, sleep, medication, socioeconomic, acceptability, and health-related survey data from survivors, siblings, and caregivers.
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