Baylor Research Institute
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
This is a retrospective review and prospective observational study involving a historical comparison which aims to compare the incidence of surgical site infection (SSI) from the time frame of January 2023 to June 2024, among approximately 900 hysterectomies who received traditional IV antibiotics, to a matched number of hysterectomies starting in December 2026. This study seeks to determine if a one-time dose of Xaciato postoperatively can reduce the hospitals vaginal cuff infections, to investigate effective means of preventing gynecologic SSI and to test for the presence of bacterial vagino…
Inclusion Criteria: * All hysterectomies (TAH, TVH, TLH, robotic), including oncology cases and those in conjunction with pelvic floor reconstruction cases (estimated 900 cases/year) performed at Baylor Scott and White Memorial Hospital over a three-year period. * Ages 18 years old and older Exclusion Criteria: * Pre-existing infection, including known untreated bacterial vaginosis. * Allergies to clindamycin * Pregnancy
Vaginal clindamycin gel placed at the end of hysterectomy to prevent surgical site infection
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