NYU Langone Health
The purpose of the study is to evaluate the safety and feasibility of daily-adaptive post-prostatectomy stereotactic body radiotherapy (SBRT) to the prostate fossa in men undergoing salvage radiotherapy after radical prostatectomy.
Patients will have a computed tomography (CT) or Magnetic resonance imaging (MRI) simulation visit as part of the standard of care (SOC), which will be used for treatment planning. Approximately two weeks after the simulation visit, patients will receive adaptive stereotactic body radiation (SBRT) to the prostate fossa at 35 Gy in 5 fractions on the Unity (MR-linac) or Ethos (CT-linac) as SOC. The radiation treatment used in this study is SOC, however, the doses used are investigational and well supported with evidence from clinical trials.
Inclusion Criteria: 1. Patients at or over 18 years old. 2. Have a histologically confirmed diagnosis of prostate adenocarcinoma status post radical prostatectomy who are candidates for salvage postoperative radiotherapy. This includes patients whose Prostate-Specific Antigen (PSA) does not fall to undetectable levels after prostatectomy or that have undetectable PSA after prostatectomy with a subsequent detectable PSA that increases on \> 2 determinations or increases to PSA \> 0.1 ng/ml. It also includes patients with adverse pathologic features at the time of prostatectomy (e.g. positive s…
35 Gy / 5 fx to prostate fossa every other day * 25 Gy nodes ± 40 Gy boost * short-course Androgen Deprivation therapy (ADT)
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