University of Miami
The purpose of this study is to determine if injections of aflibercept into the eye given at the end of the Ahmed tube surgery as well as at postoperative months one and two would improve eye pressure control compared to standard surgery with no aflibercept.
Inclusion Criteria: * Age 18 to 85 years, inclusive. * Open-angle glaucoma (primary or secondary such as pseudoexfoliative, pigmentary, steroid response) that is inadequately controlled on tolerated medical therapy with intraocular pressure greater than or equal to 18 mm Hg and less than or equal to 40 mm Hg. Exclusion Criteria: * Unwilling or unable to give consent, unwilling to accept randomization, or unable to return for scheduled protocol visits. * No light perception vision. * Prior aqueous shunt or cyclodestructive procedure. * Prior exposure to anti-VEGF in either eye. * Diabetic re…
Aflibercept 8 mg will be administered intravitreally at three time points: immediately after Ahmed tube surgery, at postoperative month 1, and at postoperative month 2.
Participants will receive standard of care Ahmed tube surgery.
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