Memorial Sloan Kettering Cancer Center
The purpose of this study is to find out whether it is practical (feasible) to use a new type of imaging scan called 68Ga-FAPI PET/MRI (positron emission tomography/magnetic resonance imaging) to evaluate how well breast cancer responds to neoadjuvant chemotherapy.
Inclusion Criteria: * Age ≥ 18 * ECOG Performance Status of ≤ 2 * Ability to review and signed informed consent * Histologically confirmed, newly diagnosed invasive breast cancer * Lymph node metastases (either histologically confirmed or radiographic evidence of lymph node metastases). * Planned to undergo SOC NAC prior to surgical resection as outlined in section 4.1 Exclusion Criteria: * Pregnancy or lactation. * Patients who cannot undergo PET/MRI scanning because of: * devices or implants that are not MRI safe * hypersensitivity or known allergy to gadolinium-based contrast agents…
68Ga-FAPI-PET/MRI is conducted 3 times in every participant.