University of Minnesota
This pilot study will evaluate whether the MBP® Breath Analyzer can collect measurable volatile organic compound signals from pediatric participants with acute respiratory illness and from healthy pediatric controls. Children aged 7 to 17 years presenting to the Masonic Children's Hospital Pediatric Emergency Department will be enrolled. One group will include participants with signs or symptoms of acute respiratory illness, and the control group will include participants presenting for minor injuries without respiratory symptoms. Participants will breathe normally into the MBP® Breath Analyzer for approximately 1 minute. VOC signal data will be analyzed to assess device performance and to explore whether breath VOC patterns differ between pediatric participants with respiratory infection and healthy controls.
Volatile organic compounds are produced by metabolic processes and may vary across disease states, including infections. The MBP® Breath Analyzer is designed to detect volatile organic compound patterns in exhaled breath using graphene-based nanosensors and pattern recognition algorithms. This prospective pilot study will evaluate the feasibility and performance of the MBP® Breath Analyzer in pediatric participants. The study will enroll up to 20 children aged 7 to 17 years in the Masonic Children's Hospital Pediatric Emergency Department. Up to 10 participants will have signs or symptoms of…
Inclusion Criteria for Acute Respiratory Illness Group:: * Age 7 to 17 years * Able to participate in study procedures, including breathing comfortably into the MBP® Breath Analyzer for 1 minute * Meets the case definition of acute respiratory illness, defined as two or more of the following signs or symptoms: fever, cough, runny nose, nasal congestion, or sore throat Inclusion Criteria for Control Group: * Age 7 to 17 years * Able to participate in study procedures, including breathing comfortably into the MBP® Breath Analyzer for 1 minute * Does not have symptoms of acute respiratory illn…
The MBP® Breath Analyzer is a handheld breath sensor connected to a secure dedicated study mobile phone with the Vocxi app. A mask is connected to the device, and the participant breathes normally into the mask for approximately 1 minute. The system collects volatile organic compound signal data from exhaled breath for research analysis. The device will not be used to diagnose, treat, or guide clinical care.
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