University of Wisconsin, Madison
The investigators hope to learn if lobular breast cancer can be identified using a special procedure called a positron emission tomography (PET) magnetic resonance image (MRI) scan, collectively a PET/MRI scan, that uses a radioactive imaging agent called Fluorine 18 fluoroestradiol (18F-FES). This procedure may be able to define the extent of disease more clearly than the standard of care breast imaging exams. 30 participants will be enrolled and be on study for up to 6 months.
This prospective study aims to estimate the added value of supplemental 18F-FES PET/MRI following standard-of-care (SOC) preoperative assessments for detecting occult disease in ILC. The investigators hypothesize that there is increased sensitivity of 18F-FES PET/MRI for detecting additional locoregional and distant site(s) of disease that is occult on SOC imaging. Primary Objective: To estimate the increased sensitivity of 18F-FES PET/MRI for detecting disease that is occult on SOC imaging Secondary Objectives: To characterize the * Positive predictive value of additional pathology-confirm…
Inclusion Criteria: * Adults assigned female sex at birth * Newly diagnosed ILC confirmed on core-needle biopsy (greater than or equal to 1 percent ER staining per ASCO/CAP guidelines) * have undergone or will undergo standard-of-care (SOC) clinical and imaging assessments (e.g., mammography, ultrasound, breast MRI) * planning for mastectomy or breast-conserving surgery within 12 months of their initial diagnosis * Provision of signed and dated informed consent form Exclusion Criteria: * Patients with history of ipsilateral axillary lymph node dissection * Patients who received anti-estroge…
* Dose: Approximately 6 mCi (222 MBq) ± 20% * Administration: IV injection, contralateral to the primary tumor site * Physical Half-life: \~110 minutes * Mechanism: FES binds to estrogen receptors expressed on tumor cells, enabling visualization of ER-positive disease sites.
Participant undergoes PET/MRI scan to image ER-positive disease sites
Administered during the MRI portion of the examination
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