Washington University School of Medicine
This study is being done to better understand how the immune system responds to vaccination against influenza and rabies. Researchers want to study how immune responses develop and change over time in the blood and in the lymph nodes that drain the vaccination site, following vaccination with two vaccines licensed by the U.S. Food and Drug Administration (FDA): the seasonal trivalent influenza vaccine (TIV) and the rabies vaccine (RabAvert). By studying these samples, researchers hope to learn how the body produces high-quality, long-lasting antibody and memory immune responses after vaccination. The study will also compare immune responses in younger adults to immune responses in older adults, because prior research suggests that the immune system's ability to respond to vaccination weakens with age.
Inclusion Criteria: 1. Healthy participants 18 to 40 years of age or ≥65 years of age. 2. Able to understand and give informed consent. 3. Willing to receive RabAvert vaccine. 4. Willing to receive TIV (trivalent influenza vaccine). 5. In stable health, as determined by medical history and targeted physical exam related to this history. 6. Willing to give blood and optional lymph node FNA (fine needle aspiration) samples. Exclusion Criteria: 1. Has a history of severe local or systemic reactions to any vaccination. 2. Has a history of severe allergic reaction to any component of the rabies…
Standard, seasonal flu vaccines
Rabies vaccine for pre-exposure
Arctuva estimate
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