Wake Forest University Health Sciences
This study is being done to find out if methadone is more effective in controlling pain in patients presenting for minimally invasive lung resection surgery compared to the standard of care.
Emerging evidence suggests that long-acting opioids may provide more stable analgesia and reduce overall opioid requirements in the perioperative period. However, the role of methadone as part of a multimodal analgesic regimen in minimally invasive lung resection surgery has not been well-defined. This randomized controlled trial aims to address this gap by directly comparing methadone-based analgesia to standard of care in patients undergoing elective minimally invasive lung resection surgery.
Inclusion Criteria * Scheduled for minimally-invasive lung resection surgery (for example, wedge, lobe, segmentectomy, combination of aforementioned procedures) * Elective same day admission cases Exclusion Criteria * Daily use of \>/= 60 MME for 1 month or greater * Weight \< 50 kg * Baseline oxygen requirement * Chronic Kidney Disease Stage 4 or 5 * Diagnosis of cirrhosis or liver failure * Left ventricular ejection fraction \< 30% * Conversion to thoracotomy
intraoperative methadone 0.1mg/kg on induction, based on actual body weight, maximum of 10 mg
any standard of care analgesic at discretion of the anesthesia team not including methadone
Arctuva estimate
Actual pay is set by the research site.
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