Yale University
Evaluate (S)-\[18F\]FBFP and (R)-\[18F\]FBFP, sigma-1 radiotracers, in humans, to characterize their pharmacokinetic, metabolic, and in vivo binding profiles, assess feasibility for quantitative kinetic modeling analysis of imaging data, and determine the reliability and reproducibility of kinetic and binding parameters. Assess specific binding levels of (S)-\[18F\]FBFP or (R)-\[18F\]FBFP by conducting test-block studies in humans.
Inclusion Criteria: * Willing and able to give voluntary written informed consent * Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff * Male or female, aged 18 to 60, at screening * In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry, hematology, and serology tests. * Females of childbearing potential, and male subjects, must be willing to practice birth control for the duration of the study (unless medical documentatio…
Novel radioisotope aimed at imaging the sigma1 receptors in the brain
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