University of California, San Diego
To Evaluate Feasibility and Exploratory Clinical and Biomarker Signals of NRPT in Adults with Knee Osteoarthritis
This exploratory study will evaluate the feasibility, tolerability, and preliminary effects of NRPT (nicotinamide riboside plus pterostilbene) in adults with knee osteoarthritis. Participants who qualify based on the screening will take 2 capsules twice daily for 12 weeks and complete questionnaires and a walking test to assess knee pain, physical function, and quality of life. Blood and urine samples will also be collected to evaluate markers related to inflammation, NAD+, and cartilage health. The information collected may help researchers understand the potential effects of NRPT and guide…
Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the planned 14-week duration of participation. 3. Adults aged 18 to 80 years (inclusive) at the time of consent, of any sex. 4. Unilateral symptomatic radiographic KOA defined as Kellgren-Lawrence (KL) grade 2 or 3 in the tibiofemoral joint of the index knee, as determined from a standing knee radiograph obtained within the prior 12 months or at Screening. 5. Knee pain in the index knee with a Visual Analogue Scale (VAS) score of 20-80 (on…
EH301 is a higher-dose NRPT supplement containing nicotinamide riboside (NR) and pterostilbene (PT). Each capsule contains 250 mg of nicotinamide riboside and 50 mg of pterostilbene
Arctuva estimate
Actual pay is set by the research site.
Verify or correct the compensation shown for this listing.