Boston University Charles River Campus
The objective of this study is to apply state-of-the art brain imaging approaches to evaluate new hypotheses about the contributions of core linguistic vs. domain-general executive systems to language processing and recovery in patients with varying degrees of linguistic impairment. Specifically, the investigators will first characterize the degree to which standard language assessments tax the domain-general Multiple Demand (MD) network (Aim 1). And then systematically investigate the causal contributions of the language and the MD networks to language processing and aphasia recovery in patients of varying severity (Aims 2 and 3).
Inclusion Criteria: * at least 12 weeks post-stroke at time of study enrolment * medically and neurologically stable (no active seizures for 6 months) and at least wheelchair ambulatory * premorbid fluency in English * a family member or caregiver available to assist in study setup and in communicating with study staff Exclusion Criteria: * a major, active neurological condition other than stroke, as determined by medical record review * history of cognitive impairment unrelated to stroke, such as dementia * history of symptomatic stroke prior to index stroke * severe uncorrected vision and…
The Constant Therapy program includes includes 91 therapy exercise programs and participants can practice any of the exercises in the program for 50 hours (60 minutes a day, 5 days a week for 10 weeks).
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