University Hospitals Cleveland Medical Center
Sickle cell disease causes very painful episodes that can happen without warning. Pain is one of the biggest problems for people with SCD. Medicines like opioids can help, but they have serious side effects. Doctors are looking for other ways to treat pain. Investigators have already found that music therapy - breathing exercises guided by a trained music therapist - can lower pain in adults with SCD. But investigators don't know exactly how it works yet inside the body. This study will look at two possible reasons why music therapy helps: * It may calm the body's "fight-or-flight" (sympathetic) nervous system, which can make pain worse when it is too active. * It may boost the "calming" (parasympathetic) nervous system, which may ease pain and reduce inflammation. * It may lower swelling and inflammation in the body, which also drives pain.
Inclusion Criteria: * (1) are age ≥18 years * (2) have a diagnosis of SCD documented in the electronic health record (EHR)--- (3) meet Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy (AAPT) criteria for chronic SCD pain * (4) are able to speak and understand English * (5) have an email address and access to a mobile device with a functioning data plan (to get pain diaries) * (6) report that pain interfered with daily activities at least 1-2 days in past week will be eligible for the study. - Exclusion…
Participants will undergo a 20-minute music therapy session with a board certified music therapist, then will repeat this on their own once daily for 2 weeks.
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