University of Arizona
The goal of this study is to evaluate the EPISEEK-MPE laboratory test for diagnosis of malignant (cancerous) pleural effusions verses pleural effusions caused by a non-cancer condition. The study uses excess samples drained from around the lung as part of a patient's regular care. The main questions the study aims to answer are: 1. Is the EPISEEK-MPE test reliable to detect cancer cells and aid in the diagnosis of malignant pleural effusions? 2. Do age, race, gender and ethnicity change the reliability of the EPISEEK-MPE test? 3. Can the results of the EPISEEK-MPE test predict which patients have a better chance of survival than others? Participants will be asked to donate a small portion of the excess fluid drained from around the lung for research. Participants will also give permission to collect data from the medical records.
In clinical practice, it remains a challenge to distinguish between malignant pleural effusion (MPE) and benign pleural effusion (BPE). Because of the limitations of conventional cytology methods, there is an urgent need to develop a more accurate and effective method for the efficient diagnosis of MPE. In collaboration with the University of Arizona, Precision Epigenomics has developed the EPISEEK-MPE test that has the potential to be an effective complimentary tool for cytology in the process of differential diagnosis. The aim of this project is to conduct a multi-site clinical validation st…
Inclusion Criteria: * Adult patients having pleural fluid drained for clinical care (thoracentesis or chest tube placement) * Consent to have pleural fluid sample used for research Exclusion Criteria: \- Insufficient fluid available following clinical drainage procedure
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