University of Pittsburgh
The goal of this study is to (1) determine the feasibility and acceptability of a telehealth-delivered exercise intervention (including resistance and aerobic training) during neoadjuvant chemotherapy (NACT) for women with high-grade serous ovarian cancer (HGSOC) and to (2) determine the effect of exercise on changes in immune function, inflammation, and treatment response.
Inclusion Criteria: * Women, age ≥ 18 years old * Diagnosed with high-grade serous ovarian cancer * Treatment plan includes neoadjuvant chemotherapy followed by potential interval debulking surgery at UPMC Magee Womens Hospital, UPMC Hillman Cancer Center, UPMC Shadyside Hospital, or UPMC Passavant Hospital * Consented to participate in STUDY19060197: HCC 07-058 * Neoadjuvant chemotherapy has not yet been initiated * ECOG Performance Status Scale score of ≤ 2 * Ability to provide written informed consent * Ability to understand, speak, and read English. (Many of the study instruments utilized…
The exercise intervention will last approximately 9-12 weeks, running concurrently with their neoadjuvant chemotherapy, and will include resistance training two times per week and aerobic exercise 3-5 times per week. The prescribed exercise will be personalized based on the participant's baseline functionality and will be adjusted as needed throughout their participation based on any disease or chemotherapy-related side effect.
The UC group will not receive any intervention during study participation and undergo usual medical treatment and surveillance during the duration of the study.
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