Rhode Island Hospital
This Stage II behavioral intervention development project will examine the efficacy of a multi-domain health behavior intervention for primary prevention of Alzheimer's disease and related dementias (ADRD) in middle age.
The 8-week, remotely-delivered TEACH intervention was designed to promote maintenance, not just initiation, of health behaviors that reduce risk for ADRD. This randomized controlled trial (N=140 per arm; 1:1 allocation) will examine the efficacy of TEACH versus basic health education alone at end of treatment (8 weeks) and 4- and 12-month follow-up. We will examine the efficacy of the intervention on a multidomain behavioral composite score and individual health behaviors related to dementia risk (Aim 1) and biological outcomes including metabolic syndrome severity and a proteomic dementia ris…
Inclusion Criteria: 1. Age 40-69 years 2. Normal cognition (Telephone Interview for Cognitive Status-Modified \> 32) 3. English language fluency 4. Participants must have at least two of six dementia risk factors: 1. BMI in the overweight or obesity range ( \>24.9) 2. Systolic blood pressure in the "elevated" range or higher (\>120 mmHg) 3. LDL cholesterol outside the "optimal" range (\>100 mg/dL) 4. HbA1C in the prediabetes or diabetes range (\> 5.6%) 5. APOE e4 allele 6. First-degree relative with ADRD 5. Participants must have suboptimal engagement in at least one core h…
The TEACH intervention provides a personalized assessment of and education about ADRD risk factors and health belief traits that are evidence-based moderators of behavior change. The 8-week, remotely delivered group intervention educates participants about 16 modifiable risk factors for ADRD. TEACH includes a personalized goal-setting process and education about health beliefs that are barriers or facilitators of behavior change.
The basic health education is an 8-week, remotely delivered group intervention that educates participants about 16 modifiable risk factors for ADRD.
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