University of Wisconsin, Madison
The goal of this clinical trial is to learn if one course of low-dose radiation therapy (LDRT) helps as much as two courses of LDRT in people with osteoarthritis. The main questions it aims to answer are whether pain control, joint function, and quality of life are the same with one course of LDRT. Participants will receive LDRT and can expect to be in the study for up to 3 months.
This study is being done to evaluate the degree of symptom improvement after dual-course low-dose radiation therapy (LDRT) compared to single-course LDRT in participants with osteoarthritis (OA) of the knee.
Inclusion Criteria: * Clinical diagnosis of osteoarthritis of the knee * Age ≥40 years at the time of consent * Joint pain which has persisted for ≥3 months * Completed imaging of the involved joint in the past 3 months (including MRI, CT, X-ray, or bone scan) * Negative pregnancy test Exclusion Criteria: * Previous surgery to the affected joint or planned surgery to the affected joint in the next 6 months * Previous radiation treatment targeting the affected joint. Previous radiation targeting any other body site does not exclude from participation as long as there is no clinically meaning…
Treatments will be given twice weekly over a duration of approximately 3 weeks.
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