Massachusetts General Hospital
The purpose of this study is to evaluate the feasibility and tolerability of the Optical Coherence Tomography (OCT) capsule during routine High Resolution Anoscopy (HRA) at Massachusetts General Hospital (MGH).
Using the Optical Coherence Tomography (OCT) tethered capsule to image the anal canal during routine HRA appointments the investigators will compare OCT image features to available histopathologic diagnoses of anal lesions. The primary outcome will be to determine whether OCT imaging can reliably detect dysplasia in the anal canal.
Inclusion Criteria: * Adults ≥18 years old * Undergoing HRA * Ability to provide informed consent Exclusion Criteria: * Recent anorectal procedure or surgery * In care for anal fissure, fistula in-ano, or recent anorectal trauma * History of fissurectomy, fistulotomy, anal stricture, or other post-surgical abnormality that may interfere with imaging * Unable to undergo biopsy due to history of bleeding disorders or current anticoagulant therapy
Obtaining Optical Coherence Tomography images of the anal canal to evaluate feasibility and tolerability to detect dysplasia in the anal canal
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